In this subgroup, we combine small molecule self-assembly with polymer chemistry to produce Single-Chain Polymeric Nanoparticles (SCPNs). Our aim is to explore the limits of SCPNs in terms of structural control, characterization and utilization. Hereto, we work towards controlled folding of synthetic polymers as well as nanoparticles with improved conformational control. Furthermore, we use functionalized SCPNs to fulfill SCPN-accelerated catalysis of specific reactions in both aqueous and complex cellular environments.